Research on Biomedical Engineering
http://rbejournal.org/article/doi/10.1590/2446-4740.180040
Research on Biomedical Engineering
Original article

The temporal stability of recurrence quantification analysis attributes from chronic atrial fibrillation electrograms   

Tiago Paggi de Almeida, Fernando Soares Schlindwein, João Salinet, Xin Li, Gavin Shen-Wei Chu, Jiun Haur Tuan, Peter James Stafford, G André Ng4, Diogo Coutinho Soriano 

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Abstract

Introduction: The temporal behavior of atrial electrograms (AEGs) collected during persistent atrial fibrillation (persAF) directly affects ablative treatment outcomes. We investigated different durations of AEGs collected during persAF using recurrence quantification analysis (RQA). Methods: 797 bipolar AEGs with different durations (from 0.5 s to 8 s) from 18 patients were investigated. Four RQA-based attributes were evaluated based on AEG durations: determinism (DET); recurrence rate (RR); laminarity (LAM); and diagonal lines’ entropy (ENTR). The Spearman correlation (ρ) between each duration versus 8 s was calculated. AEG classification was performed following the CARTO criteria (Biosense Webster) and receiving operating characteristic (ROC) curves were created for the RQA variables. Results: The RQA variables successfully discriminated the AEGs: the area under the ROC curves were as high as 0.70 for AEGs with 3.5 s or greater. Three types of AEGs were found using these variables: normal, fractionated and temporally unstable. The number of unstable AEGs decreased with longer AEG segments. Different AEG durations significantly affected the RQA variables (P<0.0001), with no statistical difference between the durations 6 s, 7 s and 8 s for DET, LAM and ENTR, and no difference between 7 s and 8 s for RR (P<0.0001). AEGs with 3 s or longer have shown ρ ≥ 80% for all variables. Conclusion: The RQA variables have been shown effective in the characterization of AEGs collected during persAF with a shorter duration than current recommendations, which motivates their use for the characterization of atrial substrate during persAF ablation. 

Keywords

Persistent atrial fibrillation, Fractionated electrograms, Catheter ablation, Electrophysiology mapping, Recurrence plots, Recurrence quantification analysis. 

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